Eczema Skin Disease
Serious Eczema Symptoms Beyond the Skin with Jonathan Silverberg, MD, PhD, MPH
Scientists believe that atopic dermatitis involves a defective skin barrier that allows allergens to enter the skin and interact with immune cells to cause inflammation. Several proteins have been identified that may be involved in this response. One is thymic stromal lymphopoietin TSLP , which has also been linked to asthma and to a food allergy-related disorder called eosinophilic esophagitis. TSLP expression is elevated in mice with atopic dermatitis. Past work led by Dr. Ctip2 was also found to be important for skin lipid metabolism, which keeps the skin healthy and hydrated. In the new study, Indra's team set out to explore the role of Ctip2 in the skin of adult mice.
The team genetically altered mice to remove Ctip2 from epidermal outer layer skin cells. The team identified an age-dependent increase in certain inflammatory cells in the skin of the mice lacking Ctip2. Ctip2 deficiency also caused systemic inflammatory responses. The altered mice had enlarged lymph nodes and spleens, as well as high levels of circulating inflammatory proteins. Expression of genes known to be involved in mouse and human atopic dermatitis, including TSLP, increased in mouse skin when Ctip2 was absent. TSLP levels were up to 1,fold higher. Future research will be needed to determine precisely how repression of TSLP by Ctip2 might protect against disease.
References: PLoS One. Epub Dec Having more water in your skin can help you heal faster. Avoid irritating your sensitive skin: Dry, sensitive skin is more likely to have frequent flare-ups of nummular eczema. For this reason, your treatment plan may include instructions that can help you avoid irritating your skin. Use only a mild, non-drying cleanser to wash your skin, applying it only to skin that needs washing, like the armpits, feet, and groin. Treat the spots and patches on your skin: To help clear the eczema, your dermatologist will prescribe medication or light treatments. Most people will apply one of these medications:. For best results, you may need to apply your medication to damp skin immediately after bathing.
This can help the medication heal your skin more quickly. If you have widespread spots and patches, you may need stronger treatment. Your dermatologist may prescribe medicated dressings that you will apply or a corticosteroid medication that you take. Some patients receive an injection of corticosteroids. For some people, a light treatment called phototherapy may be an option.
To receive light treatments, you will need to go to a phototherapy treatment center or hospital a few times a week for several weeks. Get rid of infection: If you developed an infection, your dermatologist will prescribe medication to help clear the infection. You may need to apply this medication directly to your skin or take pills. Help you sleep: If the itch keeps you awake, your dermatologist may recommend taking an antihistamine that makes you drowsy. Being well-rested can help your skin to heal. Once the eczema starts to clear, the itch tends to go away. Once treatment starts to work, your dermatologist may change your treatment plan. This helps to reduce possible side effects from medications while helping your skin clear. Sometimes, treatment fails to work.
If this happens, keep your dermatology appointment. You may need a different medication. If your dermatologist suspects that you have an undiagnosed allergy, your dermatologist may recommend patch testing. Patch testing can be extremely helpful for people who continue to have flare-ups of nummular eczema. Researchers have found that when nummular eczema fails to go away, the reason is often an allergy. Finding and treating an allergy helps some people get rid of nummular eczema.
With proper treatment, nummular eczema can clear completely. Self-care also plays an important role. See what dermatologists recommend by going to: Nummular eczema: Self-care. Jiamton S, Tangjaturonrusamee C, et al. Last updated November Purnamawati S, Indrastuti N, et al. Clin Med Res. Reider N, Fritsch PO. Mosby Elsevier, China, Trayes KP, Savage K, et al. Am Fam Physician. Childhood eczema Could my child have eczema?Researchers have found that when nummular eczema fails Slave And Francisco Pzarro Research Paper go away, the reason is Lord Of The Flies Weather Analysis an allergy. Eczema is not contagious. My skin literally had split. Zsa Zsa: I would just stay Delivering Customer Service Case Study my cubicle and not go Slave And Francisco Pzarro Research Paper and see people.