Disease Outbreak News Report

Tuesday, December 14, 2021 1:30:51 AM

Disease Outbreak News Report



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Infectious Disease News was unable to confirm relevant financial disclosures for Klain and Steiger at the time of publication. By Gerard Gallagher. Read next. January 11, Receive an email when new articles are posted on. Please provide your email address to receive an email when new articles are posted on. You've successfully added to your alerts. You will receive an email when new content is published. Click Here to Manage Email Alerts.

We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice slackinc. Back to Healio. Experts speculated about the infectious disease threats Donald Trump will face as president. Related Content. Please refresh your browser and try again. Our study clearly confirms, experimentally, the potential risk for interspecies oral transmission of the agent of L-BSE. In our model, this risk appears higher than that for the agent of classical BSE, which could only be transmitted to mouse lemurs after a first passage in macaques We report oral transmission of the L-BSE agent in young and adult primates. Transmission by the IC route has also been reported in young macaques 6,7. A previous study of L-BSE in transgenic mice expressing human PrP suggested an absence of any transmission barrier between cattle and humans for this particular strain of the agent of BSE, in contrast to findings for the agent of classical BSE 9.

Thus, it is imperative to maintain measures that prevent the entry of tissues from cattle possibly infected with the agent of L-BSE into the food chain. Title: The agent of H-type bovine spongiform encephalopathy associated with EK prion protein polymorphism transmits after oronasal challenge. Citation: Greenlee, J. The agent of H-type bovine spongiform encephalopathy associated with EK prion protein polymorphism transmits after oronasal challenge. Prion , May , , Santiago de Compostela, Spain.

Paper No. P98, page Interpretive Summary:. Technical Abstract: In , a case of H-type bovine spongiform encephalopathy BSE was reported in a cow with a previously unreported prion protein polymorphism EK. Although the prevalence of the EK polymorphism is low, cattle carrying the K allele develop H-type BSE with a rapid onset after experimental inoculation by the intracranial route. The purpose of this study was to investigate whether the agents of H-type BSE or H-type BSE associated with the EK polymorphism transmit to wild type cattle or cattle with the K allele after oronasal exposure.

Cattle were observed daily throughout the course of the experiment for the development of clinical signs. At approximately 50 months post-inoculation, one steer EK inoculated with EK associated H-BSE developed clinical signs including inattentiveness, loss of body condition, weakness, ataxia, and muscle fasciculations and was euthanized. Enzyme immunoassay confirmed that abundant misfolded protein was present in the brainstem, and immunohistochemistry demonstrated PrPSc throughout the brain. Western blot analysis of brain tissue from the clinically affected steer was consistent with the EK H-type BSE inoculum. With the experiment currently at 55 months post-inoculation, no other cattle in this study have developed clinical signs suggestive of prion disease.

These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains. P98 The agent of H-type bovine spongiform encephalopathy associated with EK prion protein polymorphism transmits after oronasal challenge. In , a case of H-type bovine spongiform encephalopathy BSE was reported in a cow with a previously unreported prion protein polymorphism EK. This study demonstrates that the H-type BSE agent is transmissible by the oronasal route.

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Home » Animal diseases » Mad cow disease reported in two Brazil states. Mad cow disease reported in two Brazil states. Animal diseases , Headlines , Latin America and the Caribbean. Atypical BSE The Group discussed and endorsed with minor revisions an overview of relevant literature on the risk of atypical BSE being recycled in a cattle population and its zoonotic potential that had been prepared ahead of the meeting by one expert from the Group. Interpretive Summary: Technical Abstract: In , a case of H-type bovine spongiform encephalopathy BSE was reported in a cow with a previously unreported prion protein polymorphism EK.

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